Spain face Ronald Koeman's Netherlands away on Thursday before returning home for the second-leg on March 23.
Valencia lost ground in the battle with Atletico Madrid and Sevilla for third place in La Liga when they conceded a late Aritz Aduriz equaliser in a bad-tempered 1-1 draw at Athletic Bilbao on Thursday.
Spain manager Luis de la Fuente left Barcelona's 17-year-old defender Pau Cubarsi and midfielders Marcos Llorente and Aleix Garcia out of his 26-man squad
Fernando Llorente netted a dramatic late winner for Athletic Bilbao to eliminate Sporting and Atletico Madrid comfortably held on to a first-leg lead to oust La Liga rivals Valencia on Thursday and set up an all-Spanish Europa League final.
Athletic Bilbao checked promoted Villarreal's impressive early-season run when they beat the team with the distinctive canary-yellow strip 2-0 at their new San Mames stadium in La Liga on Monday.
Athletic Bilbao survived a constant state of siege to hold a weakened Barcelona to a 0-0 draw at the Nou Camp in a King's Cup last 16 first-leg match on Tuesday. La Liga leaders Barca had won 10 successive games in all competitions, scoring 31 goals in the last seven, but they ran out of ideas against their resolute Basque visitors.
An ineffectual Barcelona crashed to their first La Liga defeat of the season and failed to restore their three-point lead over Atletico Madrid at the top when they were beaten 1-0 at Athletic Bilbao on Sunday.
Real Sociedad won 1-0 at Athletic Bilbao in a Basque Country derby to end its winless run and strengthen its hold on third place in the Spanish league
Athletic Bilbao missed a chance to tighten their grip on Spain's fourth Champions League qualification place when they had to come from behind to rescue a 1-1 draw at 10-man Villarreal in La Liga on Monday.
Goals from Ronaldo and Roberto Carlos moved Real Madrid up to second in the Primera Liga on Sunday.
Manchester United were handed a tricky Europa League last 16 tie against Real Sociedad while Tottenham Hotspur will play Dutch side AZ Alkmaar after the draw was held on Friday, but both managers are more concerned about their Premier League form.
Barcelona's Bojan Krkic scored twice in a 4-1 home win over Athletic Bilbao that put his side three points clear at the top of La Liga on Saturday.
Aritz Aduriz's second half hat-trick sent Barcelona spinning to a shock 4-0 defeat at Athletic Bilbao in the first leg of the Spanish Super Cup on Friday.
Athletic Bilbao have proudly resisted pressure to abandon their policy of only recruiting players of Basque origin, making it all the more impressive that they are the club standing between Barcelona and a record-extending 27th King's Cup.
Lionel Messi netted two late goals as champions Barcelona thrashed Sevilla 4-0 on Saturday to stretch their advantage over second-placed Real Madrid at the top of La Liga to five points.
Athletic Bilbao boosted their chances of securing a place in next season's Europa League when they fought back from a goal and a man down to snatch a 2-1 victory at struggling Osasuna on Sunday.
Athletic Bilbao ended tiny Mirandes's remarkable run with a ruthless 6-2 win in their King's Cup semi-final second leg on Tuesday to set up a final with either Barcelona or Valencia.
Barcelona must wait at least another week to wrap up the title after they conceded a late goal in a 2-2 draw at Athletic Bilbao in La Liga on Saturday.
Real Madrid chalked up their fifth Primera league victory in a row with a 2-0 win at Athletic Bilbao.
Three goals in a devastating nine-minute spell at the start of the second half saw Barcelona to a 4-1 win over Athletic Bilbao in the King's Cup final on Wednesday and the first of three possible titles.
IMAGES from football matches played across Europe on Wednesday.
A round-up of Tuesday's action in the UEFA Champions League.
A summary of Saturday's action in Ligue 1, LaLiga and Bundesliga.
A summary of Thursday's Europa League quarter-finals second-leg.
Villarreal's struggles in the Spanish league continued with a 2-1 loss at Athletic Bilbao, with striker Gerard Moreno not finishing the game because of an injury.
A new-look Atletico Madrid suffered a setback in their opening La Liga match of the season when they squandered several chances and twice struck the post in a 0-0 home draw with Osasuna on Sunday.
La Liga leaders Real Madrid suffered a surprise 1-0 defeat at mid-table Athletic Bilbao on Saturday after a bullet header from Aritz Aduriz in the first half secured the points.
Athletic Bilbao forward Urko Vera netted his first La Liga goal deep into added time to snatch a 2-2 draw for the Basque club at Getafe on Monday.
Lazio, who had won all four previous games, were held to a frustrating scoreless draw by a Bulgarian side who came to defend.
Athletic Bilbao ended Getafe's run of four straight wins and climbed above them into fifth place in La Liga when Aymeric Laporte's early bullet header secured a 1-0 win at the Coliseum in Madrid on Monday.
Barcelona won their 26th King's Cup when two goals from Pedro and one from Lionel Messi gave them a 3-0 victory over Athletic Bilbao in coach Pep Guardiola's final match in charge on Friday.
King's Cup holders Barcelona have a fight on their hands if they are to remain in the competition after losing a fiery first leg of their last-16 tie at Athletic Club 2-1 on Thursday despite playing the final 10 minutes with a two-man advantage. Spain striker Aritz Aduriz headed Bilbao in front in the 25th minute and the veteran produced an audacious flick to tee up youngster Inaki Williams to volley in the second three minutes later. Talisman Lionel Messi pulled a full-strength Barca side back into the game with a free-kick in the 52nd minute which came off the underside of the bar and over the line.
La Liga champions Barcelona fell to their first opening day defeat of the season in 11 years when they were beaten 1-0 at Athletic Bilbao thanks to a sensational late overhead kick from veteran striker Aritz Aduriz.
Late goals from Dani Olmo and Robert Lewandowski earned LaLiga leaders Barcelona a hard-fought 2-0 victory over Espanyol.
Aritz Aduriz nodded the first goal and set up another as Athletic Bilbao beat Espanyol 3-1 to climb to ninth in La Liga on Friday.
Real, who have smashed the La Liga scoring record, clinched their 32nd league crown and their first in four years when Gonzalo Higuain, Mesut Ozil and Cristiano Ronaldo struck in a frenetic 3-0 win at 10-man Athletic Bilbao on Wednesday.
La Liga champions Barcelona stayed on the heels of leaders Real Madrid by coasting to a 3-0 home win over Athletic Bilbao on Saturday as Lionel Messi became the club's top scorer from free kicks.
Iker Muniain gave Athletic a deserved lead in the 32nd minute by bundling the ball home after Real failed to get back in time to defend a counterattack.
IMAGES from the UEFA Champions League matches played on Tuesday
